Genetic markers of meat productivity of the Romanov sheep breed: IGFBP-3, GHo и CAST

Relevance and methods . For molecular genetic analysis, samples taken from Romanov sheep in micro-populations of the Yaroslavl region ear by pluck were isolated. Polymorphism genes type 3 protein that inhibits insulin-like growth factor (IGFBP-3), hormone (Gh), calpastatin (CAST) was studied. A selection assessment live weight indicators age periods, depending on genotype, carried out. Results Two variants IGFBP-3 gene polymorphism identified: homozygote (FF) heterozygote (FG). The frequency F G alleles 94% 6%, respectively No animals carrying gg genotype identified study population. Evaluation population GHo showed presence three genotypes AA, AB BB with allele b — 63% 37%, respectively. When evaluating CAST polymorphism, MM, MN, NN different occurrence. ratio M N 74% 26%, Indicators observed (Ho) expected (He) heterozygosity for studied are range 0.11...0.62 0.10...0.47, It found IGFBP-3FG had a significantly higher at 10 months compared to carriers IGFBP-3FF 5.7%. gene, greatest significant superiority all periods individuals GHoAB which ranged 0.5% 12.9%. Animals CASTMM outperformed CASTMN CASTNN 5 5.61% 14.8% 4.53% 11.3%, conducted research will speed up process increase profitability industry.